Syncytial Hepatitis of Tilapia – Transmission Electron Microscopy

Transmission electron micrograph from liver of fingerling tilapia with SHT. Virus particles, typical of orthomyxovirus, can be seen between and within cells (arrows).

Tilapia are considered to be relatively resistant to many of the common diseases that beset other farmed fish. Viral diseases, however, are not common, and there are only a few reports in the literature. Syncytial Hepatitis of Tilapia (SHT) is a newly described viral disease reported from several countries where tilapia farming is present. This virus is a member of the Orthomyxoviridae family. It has been demonstrated within hepatocytes of affected fish. The described ultrastructural changes provide further evidence to support the previous suggestion of...

Syncytial Hepatitis of Tilapia – Histopathology

Liver; O. niloticus L.; dissociation of hepatocytes containing brown-staining lipoprotein, degeneration and single cell necrosis, plus early hepatocellular syncytial cell formation and moderate diffuse inflammation H&E.

Syncytial Hepatitis of Tilapia (SHT) is a newly described viral disease reported from Ecuador, Israel, Colombia and several other countries where tilapia farming is present. The most consistently described target organs are the liver and gastrointestinal tract, although there are some reports of lesions within the central nervous system. The presence of a novel virus with close affinity to the family Orthomyxoviridae has been demonstrated within hepatocytes of affected fish. Histopathological lesions include necrotizing hepatitis with distinctive hepatocellular syncytial giant cell formation, dissociation of hepatocytes...

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